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| Cholecalciferol (Photo credit: Wikipedia) |
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| Adult Gummies - Calcium and Vitamin D (Photo credit: LookAfterYourself) |
Cholecalciferol: A single dose improves the serum levels for a long time
Treatment with a single high dose of vitamin D3 - cholecalciferol - proved to be effective and safe way to increase the levels of vitamin D in the body and reduce the metabolic abnormalities resulting from the lack of this fat-soluble prohormone.
A team of Italian researchers conducted a study to assess which of the two forms of vitamin D: ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) may be better to raise an effective and sustained plasma levels in patients suffering from deficiency vitamin D.
The researchers monitored the effects of a single dose of 300 thousand IU of cholecalciferol (vitamin D3) or ergocalciferol (vitamin D2) on plasma levels of 25-hydroxyvitamin D - the 25 (OH) D was used as a marker of vitamin D in the body - and the concomitant changes in key factors that regulate calcium homeostasis within 60 days of analysis.
The study , led by Professor Salvatore Minisola President of SIOMMMS (Italian Society for Osteoporosis, mineral metabolism and diseases of the skeleton) and the result of collaboration between the ' Sapienza University of Rome and ' Hospital Home for the Relief of Suffering in San Giovanni Rotondo, was published in the journal American Journal of Clinical Endocrinology and Metabolism .
The investigation involved 32 elderly women aged between 66 and 97 years with vitamin D deficiency
The intake of cholecalciferol or dell'ergocalciferolo was made orally or intramuscularly.
The patients were divided into 4 groups:
vitamin D3 orally
intramuscular vitamin D3
vitamin D2 orally
intramuscular vitamin D2
The results of the study highlight that vitamin D3 is more effective than vitamin D2 in raising serum levels of 25 (OH) D and that oral administration is better than all'intramuscolare.
These results provide useful information about the formulation of dietary supplements acts integration of vitamin D.
When the vitamins D2 and D3 are administered orally, the levels of 25 (OH) D increase in parallel demonstrating a similar absorption. After 3 days of dosing levels of 25 (OH) D decreased in the group treated with ergocalciferol plotting the subject to an insufficient level well before 60 days of analysis. This suggests a more rapid metabolism or clearance dell'ergocalciferolo compared to cholecalciferol.
The study shows that the use of a single very large dose of cholecalciferol is useful to raise and maintain the serum levels of 25 (OH) D for a long time allowing an improvement of the compliance of patients.
The data show that administration of cholecalciferol orally determines a rapid increase of 25 (OH) D while the intramuscular route causes a slow and gradual increase in time.
The study also found that concentrations of 25 (OH) D also influence the serum levels of 'parathyroid hormone (PTH). In particular, the cholecalciferol administered either orally or intramuscularly tends to lower PTH levels over the 60 days of analysis.
The ability of cholecalciferol to raise and maintain the levels of vitamin D in the body has important implications in the field of physiology and pharmacology. We must remember that the increase in serum 25 (OH) D enhances calcium absorption from the intestine, reduces PTH levels, reduces the risk of osteoporotic fractures and improves muscle strength.
In the near future the results of this study could pave the way for new and more effective treatments to counteract the negative effects of vitamin D.
L 'hypovitaminosis D is often caused by insufficient exposure to sunlight, a diet low in vitamins or diseases that alter the absorption of vitamin D.
This condition affects a greater extent in the elderly whose lifestyle and food and the presence of comorbidities lead to an increase in risk.
A diet rich in oily fish, tuna and salmon can provide a good supply of vitamin D.
The lack of vitamin D following a number of pathological conditions such as hyperparathyroidism, increased bone turnover, the risk of fractures, muscle weakness, and a tendency to fall.
And 'possible to find an association between hypovitaminosis this and many chronic diseases such as cancer, cardiovascular disease and diabetes.
The increased exposure to sunlight may improve the levels of vitamin D in the body but also increases the risk of developing skin cancer, so it is safer to take this vitamin by mouth: with diet and nutritional supplements.
In this perspective it is clear the importance of 'oral intake of cholecalciferol as a viable alternative to the natural production of vitamin D.
The opportunity to administer the vitamin D3 at high doses with intervals of several months between each dose and the other door obvious advantages for patients who can thus take the drug a few times a year rather than every day.
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