Sunday, September 30, 2012

Vitamin D Is Not Just For Bones

Vitamin D is a fat-soluble vitamin that possesses both the characteristics of a vitamin and a hormone. It is necessary for growth, especially for normal growth and development of bones and teeth in children. It protects against muscle weakness and is involved in regulation of the heartbeat. It is also important in the prevention and treatment of breast and colon cancer, osteoarthritis, osteoporosis, and hypocalcemia. It enhances immunity and is necessary for thyroid function and normal blood clotting. It can be found in three forms including vitamin D2 (ergocaliciferol) which comes from food sources, vitamin D3 (cholecalciferol) which is synthesized in the skin as a response to the exposure to the sun's ultraviolet rays, and a synthetic form vitamin D5. Vitamin D3 is considered the natural form and is the most active. Ergocaliciferol, the form we get from food, is not fully active and requires conversion by the liver and kidneys to become fully active. This is why people with liver or kidney disorders have a higher risk for developing osteoporosis. Exposing the skin to the sun's ultraviolet rays causes a cholesterol compound in the skin to be transformed into a precursor of vitamin D. Exposing the face and arms to the sun for fifteen minutes three times a week is an effective way to ensure an adequate amount of vitamin D for the body. However, it has been found by researchers that the limited amount of sunlight during the winter months in the upper third of the U.S. continent cannot produce adequate amounts by exposure to sunlight. Therefore, supplementation is required to ensure adequate amounts during the winter months. A severe deficiency of vitamin D can cause rickets in children and osteomalacia in adults. Rickets results when the lack of vitamin D affects the body's ability to absorb calcium and phosphorus. Early signs of a deficiency include nervousness, painful muscle spasms, leg cramps, and numbness of the arms and legs. Eventually, malformations of the bones may develop due to bone softening. Bowed legs, knock-knees, scoliosis, a narrow rib cage, a protruding breastbone, and/or beading at the ends of the ribs as well as tooth decay, delayed walking, irritability, restlessness, and profuse sweating. Fortunately, rickets is now very rare in the U.S. It is usually seen in children aged six to twenty-four months. Vitamin D deficiency in adults is referred to as osteomalacia and is most often related to the body's inability to properly absorb phosphorous and calcium. It is most likely to occur in pregnant women and nursing mothers, whose nutritional requirements are higher than normal, or individuals with malabsorption problems. Osteomalacia may also affect people whose diets are extremely low in fat such that adequate bile cannot be manufactured and vitamin D cannot be absorbed. This condition can be caused by kidney failure. It is difficult to diagnose osteomalacia and it often misdiagnosed as osteoporosis. Less severe deficiencies may result in loss of appetite, a burning sensation in the mouth and throat, diarrhea, insomnia, vision problems, and weight loss. The New England Journal of Medicine published a study which reported there are indications that vitamin D deficiency is much more widespread than previously thought. This is especially the case in older adults. In a group of people who had few risk factors for deficiency, 57% were found to have below-normal levels of vitamin D and 67% of those who reported a vitamin D intake below the RDI had moderate to severe deficiencies. Vitamin D should be taken with calcium and avoid mega doses of vitamin D to avoid toxicity. Toxicity can occur from taking over 65,000 international units of vitamin D over a period of two years.

About Author: Tom Nuckels is health article author and owner of the LpVitamins.com website. His customers range from children to the elderly and from carpenters to doctors. You can find more health articles when you visit http://www.lpvitamins.com.

Article Source: ArticlesAlley.com

Rhuematoid Arthritis: What Are Your Best Treatment Options?

Recent research is providing interesting insight into beneficial treatments for arthritis, especially in the area of rheumatoid arthritis. Those who are one of the more than 4 million North Americans with rheumatoid arthritis have more treatment options then ever before, with several of these options, especially when used together with one another, showing great promise for effectively managing rheumatoid arthritis. What is Rheumatoid Arthritis? Before we dive right into these highly effective treatment options, it is important to get a firm grip on what this beast called rheumatoid arthritis actually is. Rheumatoid arthritis, or RA, is a form of arthritis in which the body's immune system turns on itself and begins to attack the joints throughout the body. This causes swollen, painful joints, fever and many times deformity of the joints. Those between the ages of 20-40 are most commonly diagnosed, except in cases of juvenile RA, in which children 16 years of age or younger are typically affected. Rheumatoid arthritis is three times more likely to affect women then men, and has been shown to favor certain geographical regions with a high concentration in North America. If left untreated, RA will cause rapid degeneration and will quickly begin to deform the joints it affects, especially those in the wrists, hands and fingers. It is also commonly found in the elbow, shoulder, neck, jaw, feet, ankles, knees and hips. The affected joints will usually feel hot, consistent with the inflammatory process occurring in these joints. One of the landmark signs of rheumatoid arthritis is that the same joints will be affected on both sides of the body. What Rheumatoid Arthritis Treatments are Most Effective? Until recently prescribing expensive and slow-working drugs known as disease-modifying anti-rheumatic drugs, or DMARDs, was the favorite treatment for rheumatoid arthritis. While medication may certainly be warranted and beneficial in some cases of RA, research is revealing that a combination of dietary changes along with supplements and herbs as well as physical activity in the early stages of RA is proving to be a highly effective method of managing RA. As any health professional with tell you, prevention is always more effective than any cure, and rheumatoid arthritis is no exception. Vitamin D therapy, either through diet (dairy products - especially milk) or supplements (Vitamin D3 - cholecalciferol) has been shown to prevent auto-immune diseases including rheumatoid arthritis, multiple sclerosis and type 1 diabetes. Dosages up to 2000 units have shown promising results and also have been shown to reduce a key factor in chronic inflammation throughout the body, which commonly occurs alongside RA. Blunting the autoimmune response while at the same time reducing inflammation throughout the body is the best way to effectively manage rheumatoid arthritis. Periodic fasting can be very helpful in deadening the autoimmune response, as can taking probiotics (supplements containing beneficial microorganisms). Supplementing your diet daily with between 2-3 grams of the Omega-3 fatty acids EPA and DHA also is very beneficial in diminishing the autoimmune response. Identifying and addressing any food allergies or sensitivities, which will typically aggravate autoimmune diseases, is quite essential. It is worthwhile to note that while treatment for rheumatoid arthritis may involve introducing several supplements to your diet, supplements that are meant to enhance your immune system should be avoided. Since the immune system is already overactive, stimulating it through herbs such as Ginseng, Echinacea or others may actually make your RA worse. Inflammation is a key factor in rheumatoid arthritis treatment. The more inflammation present, no matter if it is due to a localized injury or part of a system-wide chronic condition, the worse your RA symptoms will be. Reducing inflammation is possible through supplements and herbal therapies. Omega-3 fatty acids including EPA and DHA have shown positive effects in improving joint function that are enhanced by GLA, a key element in the herb Evening Primrose. Restricting arachadonic acids, which are plentiful in eggs, red meat and organ tissue such as liver, from your diet also helps to minimize inflammation within the body. Beyond nutritional and dietary treatments for rheumatoid arthritis, herbal therapy can also be an effective means of reducing inflammation and pain associated with rheumatoid arthritis. Tumeric, Astaxanthin and Ginger extracts may reduce the need for medications for RA if used judiciously. However, it would be wise to seek expert advice before using these herbal remedies as drug interactions and gastrointestinal problems are possible. Physical activity, especially in the early stages of the disease, is showing excellent results in slowing the progression and diminishing pain associated with RA. It has been shown to provide huge improvements in joint function, fitness and mental outlook. Resistance training utilizing exercise bands and tubing along with endurance training, sports and stretching at least two times per week may well slow the progression of the disease. Interestingly enough, however, those with severe rheumatoid arthritis actually did worse when physical activity was introduced into their regular routine. As a result it is important not only to identify RA symptoms early but also to begin rheumatoid arthritis treatments as quickly as possible. Unfortunately there is no cure for RA, but the quicker you begin to manage it, the better results you will see and the slower your disease process will progress. Living with rheumatoid arthritis is never simple nor easy, but pursuing natural treatments for RA can improve the results you see in the short term and also greatly improve your long-term quality and quantity of life.

About Author: Dr. Nick Preston is a chiropractor focused on helping families enjoy greater health and founder of Wisdom and Health. Learn more about Rheumatoid Arthritis and find products which will help you achieve great results!

Article Source: ArticlesAlley.com

Thursday, September 20, 2012

The role of vitamin D in children's diets

Space-filling of the cholecalciferol molecule ...
Space-filling of the cholecalciferol molecule (vitamin D3), C 27 H 44 O, as found in the crystal structure. X-ray crystallographic data from J. Org. Chem. (1976) 41, 3476–3478. Model constructed in CrystalMaker 8.1. Image generated in Accelrys DS Visualizer. (Photo credit: Wikipedia)
English: Overview of calcium regulation (See W...
English: Overview of calcium regulation (See Wikipedia:Calcium in biology). To discuss image, please see Talk:Human body diagrams References Page 1094 (The Parathyroid Glands and Vitamin D) in: Walter F., PhD. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch, 1300, Elsevier/Saunders. (Photo credit: Wikipedia)
In some countries, milk and cereal grains are ...
In some countries, milk and cereal grains are fortified with vitamin D. (Photo credit: Wikipedia)

Vitamin D is the common name for a group of sterol compounds with biological activity of cholecalciferol. Is fat soluble, resistant to high temperature oxidation in an alkaline environment, but is decomposed under the influence of excessive UV radiation


A SOURCE OF VITAMIN D

From a nutritional point of view, the two most important forms of prowitaminowe is cholecalciferol - present in animal products, especially fatty fish, and milk and milk products, and ergocalciferol - formed under the influence of sunlight in plant foods (mainly in yeast and fungi). Their biological activity is the same.

Cholecalciferol can also be produced in the skin from 7-dehydrocholesterol under the influence of exposure to sunlight, specifically ultraviolet B (UVB). Its endogenous synthesis in favorable conditions can provide 80-90% of the daily requirement of the body. Perhaps as much as 10 - to 15-minute exposure of the entire surface of the body is sufficient to synthesize adequate amounts of vitamin. D, cholecalciferol, however, the skin is formed only when it is directly exposed to the UV rays. Leather covered even thin clothing or sunscreen application of high blocking this mechanism.

Unfortunately, Poland is located in the geographical area in which the synthesis of the skin may be insufficient, especially in autumn and winter (October to May). When the days are short and cloudy, the outdoor temperature low enough that the residence time in the fresh air is limited, and warm clothes tightly opatula body - skin synthesis drops to zero. Even in the warm and sunny summer days cutaneous synthesis depends on air pollution limiting penetration of radiation through the atmosphere, the use of sunscreen and skin pigmentation.

Exposure to sunlight is limited as in the case of elderly people with mobility problems, patients staying in hospitals and detention centers. Part of the problem also applies to children.

The biologically active form of vitamin D, necessary for intestinal calcium transport system is 1,25 (OH) 2 D (calcitriol), which is synthesized by a two-step hydroxylation of food and provitamins endogenous synthesis-ergokalcyferolu (D 2) and cholecalciferol (D 3). The first stage of the biosynthesis of the active form of vitamin. D takes place in the liver, where the enzymatic hydroxylation of the 25th carbon atom, and the next - the kidneys, the first carbon atom and is formed calcitriol (1,25-dihydroxycholecalciferol).

THE ROLE OF VITAMIN D
Vitamin D is primarily required for proper absorption of calcium and phosphate from the gastrointestinal tract, and also inhibits their loss from the body by the kidneys, and that determines the strong bones and healthy teeth. In addition, regulates the level of calcium in the blood, maintains optimal bone mineral density, it is also essential for the proper functioning of the muscular, nervous, immune and endocrine systems.

EFFECTS OF DEFICIENCY or overdose
When the body lacks wit. D, calcium absorption in the intestinal tract is very low and to keep the blood level of normal body begins to take calcium from the bones, which leads to rickets. Rickets is formed between 3 and 24 months of age, and the most at risk are children born prematurely, the children who are growing fast, little staying in the open air and have a poor appetite, making vitamin intake. D and calcium and phosphorus is deficient.

The first symptoms of rickets are irritability, anxiety, sweating head during feeding and lack of appetite. Longer-term vitamin deficiency. D leads to the softening of the occipital bone, delayed fouling ciemiączek, emphasize the frontal, the distortion of the ribs. Arched legs bent in the shape of the letter X or O, there is a delayed eruption of teeth and deterioration resistance. But keep in mind that no single symptom can not be the basis for the diagnosis of rickets. Always require a doctor's decision on the basis of the relevant research and biochemical analysis, among others. assessment of the concentration of 25 (OH) D levels (as the best indicator of the amount of substrate available for synthesis of active hormone calcitriol in the kidney and other tissues), calcium and phosphorus in the blood.


Vitamin A deficiency. D in adolescents and adults, leading to osteomalacia and osteoporosis. The excessive intake of vitamin D can cause kidney stones, kidney failure, constipation, nausea, easy fatigue is excessive thirst and renal excretion. In children, vitamin overdose. D leads to a delay in development.

WAY TO HEALTHY BONES AND TEETH - FROM EARLY Childhood 

. D vitamin  is essential for life, but especially to take care of the proper intake and appropriate supplementation during active growth and development, they grow and strengthen the bones and teeth. The infant is born with a supply of wit. D for 4-5 weeks, it has a much smaller stocks. Breastfed infants vitamin supplementation. D starts from 3 weeks of age and given prophylactically throughout the year, regardless of the weather. Modified milk-fed infants usually receive a sufficient dose of wit. D, provided that they receive the right amount of milk.



In our climate, with limited exposure to the sun - especially in autumn and winter, in the cities, where the degree of exposure to the sun is limited due to the high installation and greater air pollution, skin synthesis of cholecalciferol is sufficient. There should be sufficient dose of wit. D, preferably supplied from a food or as a supplement in pharmaceutical preparations.

FOOD RICH IN WIT. D
The main natural sources of vitamins. D is oily fish (eg salmon, mackerel, herring, sardines), milk and dairy products, butter, egg yolk and liver, but vitamin intake. D of the food products is not sufficient.

In the traditional, well-balanced diet, vitamin intake. D can be as high as 3.75 to ALG / day, provided that frequent consumption of oily fish. Keep in mind that the contents of wit. D in products such as milk, butter and egg yolk may be subject to seasonal fluctuations.

The research conducted by the Institute Danone in 2007 on a representative group of 400 children aged 4 years showed that the average daily intake of vitamins. D was 2.5 algae, ie only 25% of the recommended intake for this age. Major deficiency (vitamin D intake of less than 2/3 the recommended values) was observed in over 95% of children.

An important supplement to the diet of wit. D products are fortified with vitamin D. The vitamin . D is mainly supplemented infant products - milk and meal modified instant and margarine. You can also buy drinking milk fortified with certain vitamins and minerals, but in other European countries and the United States to supplement assortment wit. D in the diet is much broader. It is also added to fruit juices, cereals, and other popular foods.



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Practical Facts and Tables of Vitamin D (Kalcyferol)

Stick model of the cholecalciferol molecule (v...
Stick model of the cholecalciferol molecule (vitamin D3), C 27 H 44 O, as found in the crystal structure. X-ray crystallographic data from J. Org. Chem. (1976) 41, 3476–3478. Model constructed in CrystalMaker 8.1. Image generated in Accelrys DS Visualizer. (Photo credit: Wikipedia)


Features and functions: discovery of vitamin D is closely related to a condition called rickets. In 1645 Whistler described rickets, and five years later, Glisson gave her the exact clinical picture. In the eighteenth century, fish oil has been fairly widely recognized as a cure for rickets. The first fishermen used it and the peasants living in the coastal area. In 1890, Palm on the basis of the frequency of occurrence of rickets in different countries has shown that there is a high correlation between the incidence of the disease and the intensity of sunlight. Linking the role of light and nutrition in the etiology of rickets occurred only in 1924, when Hess and Weinstock and Steenbock demonstrated that exposure to ultraviolet light of certain products makes them przeciwkrzywicze properties. In 1927 Windausa and Hess demonstrated that ergosterol is converted into vitamin D. In 1931, a year later, Angew Windausa have identified as a result of irradiation of ergosterol pure crystalline vitamin D2. Six years later received vitamin D3 through exposure to 7-dehydrosterolu. Then explained that the natural vitamin produced in the skin under the influence of solar radiation. Vitamin D include vitamin D1 (kalcyferol), D2 (ergocalciferol) and D3 (cholecalciferol). Wtamina D1 is in fish oil, D2 is produced in plants exposed to ultraviolet rays, while vitamin D3 produced in the skin of humans and animals, and as one of the few vitamins the body can produce itself when exposed to sunlight, which transform human skin contained in the 7 - dehydrocholesterol (the so-called pro-vitamin D3) is transformed into cholecalciferol. Vitamin D plays an important role in the regulation of calcium and phosphorus metabolism and bone formation.This vitamin increases calcium and phosphate absorption from the gut, and also reduces the amount of calcium excreted from the body. It is also necessary for optimal skeletal formation, indirectly has a beneficial effect on the nervous system and muscle contractions in the heart. Opowiednia calcium enables efficient conduction of nerve impulses. Vitamin D prevents and reduces inflammation of the skin and regulates the secretion of insulin, and thus affect the appropriate level of sugar in the body. A positive effect on your hearing, as determined by the good condition of the inner ear ankles. Effect on bone marrow cells that produce defense cells (monocytes). 



Used name: Kalcyferol, ergocalciferol, cholecalciferol, vitamin przeciwkrzywiczna 




Chemical formula: 
Ergocalciferol (D2) 

ergocalciferol, D2


Cholecalciferol (D3) 
cholecalciferol, D3




Requirement: 
Vitamin D is expressed in food in micrograms [mg] or International Units [IU]

1 Unit International [IU] = 0.025 [mg]

Dietary Reference Intakes for vitamin D for various population groups in the light of inadequate sunlight exposure *


Of the populationVitamin D
Dietary Reference Intakes [mg / day]Maximum safe dose that causes no risk of side effects [mg / day]
Children 1-3 years1563
Children 4-8 years1575
Boys 9-13 years15100
Youth 14-18 years15100
Male 19-30 years15100
Male 31-50 years15100
Male 50-70 years15100
Men over 70 years20100
Girls 9-13 years15100
Females 14-18 years15100
Women 19-30 years15100
Women 31-50 years15100
Women 50-70 years15100
Women over 70 years20100
Pregnant women up to 18 years15100
Pregnant women 19-30 years15100
Pregnant women 31-50 years15100
Breastfeeding women up to 18 years15100
Women who are 19-30 years15100
Women who are 31-50 years15100

* (By Dietary Reference Intakes established by the National Academy of Sciences, Food and Nutrition Board, USA) 



Sources in food: 

The content of 100 [g] or [ml] of the product[Mg]
Tran (2 tsp)242
Herring25
Mackerel24
Salmon12
Sardines in Oil9
Tuna6
Milk (1 cup)3
Wholewheat flour3
Egg (1 egg yolk)1
Liver1




Vitamin A deficiency: 
- Infants - children rickets (rachitis infantilis) 
- In older children and adolescents - late rickets (rachitis tarda) 
- In the elderly: Abnormal bone structure - osteomalacia and osteoporosis, 
- Myopia, 
- States of irritability, neurotic disorders, insomnia, pessimism, depression 



Excess vitamin: 
- Nausea, 
- Diarrhea, 
- Weight loss, 
- Tiredness, 
- Excessive sweating, 
- Loss of appetite, loss of appetite, 
- Drowsiness, 
- Delays in the development of the child, 
- Abnormal heart rhythm, 
- Increased urination; 
- Eye pain, 
- Jaw pain, joint and muscle pain, 
- Headaches, 
- Itching, 
- Increase the risk of atherosclerosis, 
- Increase the risk of kidney stones 



Which improves the absorption of: vitamin A, vitamin C, vitamin E, calcium, phosphorus, essential fatty acids, sunlight 



What affects the deterioration of absorption: alcohol, laxatives, corticosteroids 



Interesting facts about vitamin: 

- Vitamin D produced in the skin by the action of solar ultraviolet light. With nourishment mainly its initial form (pro-vitamin), which in the next stage is converted in the liver, kidneys and skin to correct vitamin D,
- Elderly people are particularly vulnerable to vitamin D deficiency created in association with the age because the skin's ability to produce this vitamin when exposed to sunlight. Guilty ago is also a lot less physical activity of older people, 
- Vitamin D is fat soluble, it facilitates its storage in the body, and therefore very high doses may cause hypervitaminosis. Hypervitaminosis D is very sporadic phenomenon, 
- Likely to be deficient in vitamin D deficiency is the most common of all the vitamins and minerals 
- Believed to have solar bath ten minutes every day during the summer months (June - early September) provides the correct dose of the vitamin. However, one should take into account individual needs, for example, that children need more vitamins than adults, and also - with age decreases the body's ability to produce this vitamin in the UV light. Also, people in polluted environments are less likely to be the right amount of vitamin D in the body. 

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Friday, September 14, 2012

Tables Nutritional foods with higher content of Vitamin C

Brussels Sprouts
Brussels Sprouts (Photo credit: Wikipedia)

Tables Nutritional foods with higher content of Vitamin C
Grape juice 340
Peppers, spicy 229
Ribes 200
Peppers, red and yellow 166
Parsley 162
Peppers, raw 151
Peppers, green 127
Milk, cow, pasteurized, skimmed 127
Milk, cow, evaporated, unsweetened 127
Turnip greens, raw 110
Rocket or rocket 110
Turnip greens, boiled 86
Kiwi 85
Brussels sprouts, raw 81
Beet leaves 81
Broccoli branchy green, raw 77
Cauliflower, raw 59
Lettuce cutting 59
Head broccoli, raw 54
Spinach, raw 54
Clementine 54
Strawberries 54
Broccoli head, boiled 53
Brussels sprouts, boiled 52
Red cabbage 52
Dandelion or dandelion 52
Oranges 50
Lemons 50
Cabbage green, raw 47
Spleen, bovine 46
Green radish 46
Orange juice 44
Tomatoes, preserves 43
Anona 43
Lemon juice 43
Grapefruit 40
Lung, bovine 40
Clementines 37
Broccoli Green branchy, boiled 35
Endive 35
Beans, fresh, raw 33
Liver, sheep 33
Peas, fresh, raw 32
Celery 32
Melon, summer 32
Liver, beef 31
Mint 31
100% Grapefruit Juice Esselunga (Zuegg) 30
Peas, frozen 30
Hero Jam Diet - Peaches 30


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Cholecalciferol: A single dose improves the serum levels for a long time

Cholecalciferol
Cholecalciferol (Photo credit: Wikipedia)
Adult Gummies - Calcium and Vitamin D
Adult Gummies - Calcium and Vitamin D (Photo credit: LookAfterYourself)

Cholecalciferol: A single dose improves the serum levels for a long time


Treatment with a single high dose of vitamin D3 - cholecalciferol - proved to be effective and safe way to increase the levels of vitamin D in the body and reduce the metabolic abnormalities resulting from the lack of this fat-soluble prohormone.
A team of Italian researchers conducted a study to assess which of the two forms of vitamin D: ergocalciferol (vitamin D2) and cholecalciferol (vitamin D3) may be better to raise an effective and sustained plasma levels in patients suffering from deficiency vitamin D.


The researchers monitored the effects of a single dose of 300 thousand IU of cholecalciferol (vitamin D3) or ergocalciferol (vitamin D2) on plasma levels of 25-hydroxyvitamin D - the 25 (OH) D was used as a marker of vitamin D in the body - and the concomitant changes in key factors that regulate calcium homeostasis within 60 days of analysis.
The study , led by Professor Salvatore Minisola President of SIOMMMS (Italian Society for Osteoporosis, mineral metabolism and diseases of the skeleton) and the result of collaboration between the ' Sapienza University of Rome and ' Hospital Home for the Relief of Suffering in San Giovanni Rotondo, was published in the journal American Journal of Clinical Endocrinology and Metabolism .

The investigation involved 32 elderly women aged between 66 and 97 years with vitamin D deficiency 
The intake of cholecalciferol or dell'ergocalciferolo was made orally or intramuscularly
The patients were divided into 4 groups:

vitamin D3 orally
intramuscular vitamin D3
vitamin D2 orally
intramuscular vitamin D2

The results of the study highlight that vitamin D3 is more effective than vitamin D2 in raising serum levels of 25 (OH) D and that oral administration is better than all'intramuscolare.
These results provide useful information about the formulation of dietary supplements acts integration of vitamin D.

When the vitamins D2 and D3 are administered orally, the levels of 25 (OH) D increase in parallel demonstrating a similar absorption. After 3 days of dosing levels of 25 (OH) D decreased in the group treated with ergocalciferol plotting the subject to an insufficient level well before 60 days of analysis. This suggests a more rapid metabolism or clearance dell'ergocalciferolo compared to cholecalciferol.

The study shows that the use of a single very large dose of cholecalciferol is useful to raise and maintain the serum levels of 25 (OH) D for a long time allowing an improvement of the compliance of patients.

The data show that administration of cholecalciferol orally determines a rapid increase of 25 (OH) D while the intramuscular route causes a slow and gradual increase in time.

The study also found that concentrations of 25 (OH) D also influence the serum levels of 'parathyroid hormone (PTH). In particular, the cholecalciferol administered either orally or intramuscularly tends to lower PTH levels over the 60 days of analysis.

The ability of cholecalciferol to raise and maintain the levels of vitamin D in the body has important implications in the field of physiology and pharmacology. We must remember that the increase in serum 25 (OH) D enhances calcium absorption from the intestine, reduces PTH levels, reduces the risk of osteoporotic fractures and improves muscle strength.

In the near future the results of this study could pave the way for new and more effective treatments to counteract the negative effects of vitamin D.

L 'hypovitaminosis D is often caused by insufficient exposure to sunlight, a diet low in vitamins or diseases that alter the absorption of vitamin D. 
This condition affects a greater extent in the elderly whose lifestyle and food and the presence of comorbidities lead to an increase in risk.

A diet rich in oily fish, tuna and salmon can provide a good supply of vitamin D.

The lack of vitamin D following a number of pathological conditions such as hyperparathyroidism, increased bone turnover, the risk of fractures, muscle weakness, and a tendency to fall.

And 'possible to find an association between hypovitaminosis this and many chronic diseases such as cancer, cardiovascular disease and diabetes.
The increased exposure to sunlight may improve the levels of vitamin D in the body but also increases the risk of developing skin cancer, so it is safer to take this vitamin by mouth: with diet and nutritional supplements.

In this perspective it is clear the importance of 'oral intake of cholecalciferol as a viable alternative to the natural production of vitamin D. 
The opportunity to administer the vitamin D3 at high doses with intervals of several months between each dose and the other door obvious advantages for patients who can thus take the drug a few times a year rather than every day.


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